The Buffalo Bills and New England Patriots will meet for the second time this month in a Week 16 matchup with major AFC playoff picture implications. The Patriots picked up the 14-10 victory in Week 13, but this week should offer much better playing conditions after the first meeting was played in extreme winds. The home side Patriots are sitting as 2.5-point favorites ahead of the divisional matchup.
Can the Bills defense stop the run after failing to do so in Week 13? Can the Patriots rebound after seeing their seven-game winning streak snapped by the Colts? Find out in our free picks, predictions, and NFL odds for Bills vs. Patriots.